Cardiac Regeneration
Treating heart disease with the power of sound
The next evolution in coronary artery disease
THE CSW SOLUTION
Refractory angina is a chronic condition in “no-option” coronary artery disease patients who suffer from long-lasting symptoms due to ischaemia, affecting:
CSW Therapeutics leverages the power of focused soundwaves to stimulate myocardial tissue on a cellular level, inducing a regenerative and angiogenic effect in myocardial tissue, leading to improved ventricular function and quality of life [3].
Restoring myocardial function and quality of life
Reducing readmission rates and cost of care
Personalized therapy and disease monitoring
The Technology
The Neowave Cardio™ device is a next-generation ultrasound therapy device, focused on ameliorating anginal symptoms and restoring cardiac function in ischemic heart disease patients.
By employing therapeutic low intensity acoustic soundwaves, the device aims to catalyze angiogenesis—the natural process of new blood vessel formation—to enhance circulatory function. Cardiac shockwave therapy has been validated in more than 50 different studies [4] to:
Enhance left ventricular function
Reduce anginal symptoms & CCS class
Improve exercise capacity and tolerance
By miniaturising and personalizing the therapy, CSW Therapeutics can improve treatment efficacy and access to care, whilst reducing costs.
NeoWave Cardio™ ultrasound therapy device
Monitoring of disease progression and treatment efficacy
Adjustable form factor for optimal therapy
Personalized and targeted therapy
Cardiac Extracorporeal Soundwave Therapy utilizes low-intensity acoustic soundwaves, functioning as gentle “wake-up calls” to propel the body’s inherent regenerative processes. As these soundwaves infiltrate bodily tissues, they instigate a mechanical disturbance within the cells, much like a tap on the shoulder, which in turn encourages cellular activation.
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the Treatment
Following this stimulation, the cells release specific signaling molecules and initiate internal repair mechanisms, marking the beginning of a transformative journey known as mechanotransduction, where mechanical inputs are converted into a cascade of biological reactions.
This synergistic cellular activity ultimately leads to angiogenesis, reduced inflammation, and enhanced tissue healing [5], essentially serving as a benevolent reminder for the body to activate its natural regenerative powers.
Rentrop Score shows the formation of collateral vessels: Grade 0 no collaterals; grade 1 side branch filling of the recipient artery without filling of the main epicardial artery; grade 2 partial filling of the main epicardial recipent artery; and grade 3 complete filling of the main epicardial recipient artery [6].
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