Cardiac Regeneration

Treating coronary artery disease with the power of sound

The CSW Solution

CSW Therapeutics is using the power of focused soundwaves to treat refractory angina, a chronic condition in no-option coronary artery disease patients who suffer from long-lasting symptoms due to ischaemia, affecting:

4.1 million

patients in the US, Europe and Japan [1], causing:

$20B

in annual costs in North America alone [2]

Using recurring & personalized focused soundwave therapy, Neowave Cardio™ use can stimulate myocardial tissue on a cellular level, inducing a regenerative and angiogenic effect, leading to improved ventricular function and quality of life [3].

Our patented Neowave Cardio™ soundwave therapy device aims to:

Investigational Device. Limited by Federal (or United States) Law to Investigational Use

Investigational Device. Limited by Federal (or United States) Law to Investigational Use

1

Restore myocardial function and quality of life in a no-option patient group

2

Reduce readmission rates and cost of patient management

3

Personalized therapy for optimal therapeutic effect

The Technology

The Neowave Cardio device is a next-generation acoustic therapy device, focused on ameliorating anginal symptoms and restoring cardiac function in ischemic heart disease patients.

By employing therapeutic low-intensity acoustic soundwaves, the device aims to catalyze angiogenesis—the natural process of new blood vessel formation—to enhance circulatory function. Cardiac shockwave therapy has been validated in more than 50 studies [4] to:

  • Reduce angina symptoms

  • Enhance left ventricular function

  • Improve exercise capacity and tolerance

By miniaturizing and personalizing therapy, CSW Therapeutics is improving treatment efficacy and therapy compliance, while improving access to care & reducing costs.

NeoWave Cardio™ ultrasound therapy device

Assessment of patient safety and personalized therapy

Adjustable form factor for optimal therapy

Personalized and targeted therapy

Cardiac Extracorporeal Soundwave Therapy utilizes low-intensity acoustic soundwaves, functioning as gentle “wake-up calls” to propel the body’s inherent regenerative processes. These soundwaves induce a mechanical disturbance within the cells, much like a tap on the shoulder, encouraging cellular activation.

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About the Treatment

These cells release specific signalling molecules and initiate internal repair mechanisms, beginning a process known as mechanotransduction, where mechanical inputs are converted into biological reactions.

This cellular activity leads to angiogenesis, reduced inflammation, and enhanced tissue healing [5], through the activation of the body’s natural regenerative powers.

Rentrop Score shows the formation of collateral vessels: Grade 0 no collaterals; grade 1 side branch filling of the recipient artery without filling of the main epicardial artery; grade 2 partial filling of the main epicardial recipent artery; and grade 3 complete filling of the main epicardial recipient artery [6].

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CSW Therapeutics AB
106 31 Stockholm, Sweden